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Fourth, residual confounding remains a fundamental limitation, as crucial variables including socioeconomic status, educational attainment, baseline cognitive reserve, lifestyle factors, and genetic risk are often inadequately captured or adjusted for in claims-based databases

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The lipid modification at the Cagri N-terminus is poorly resolved in the cryo-EM maps for AMYR complexes, but some limited density was visible for the Glu linker and a very short segment of the acyl chain in the AMY 1 R complex (Fig

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