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One observed a positive association between liraglutide use at 12 weeks and improved MMSE in 47 adults with T2DM, which correlated with increased task (verbal fluency)-based activation of the dorso-lateral prefrontal and orbitofrontal cortex, while several other cognitive tests were not affected 45

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The cAMP then binds to and activates target proteins such as Protein Kinase A, which phosphorylates specific cells in the cell via a signaling cascade pathway

These results support several publications which suggest that oxidative stress is higher in male rats than female rats 52,53

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