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You have three administration options: Option A: Injectable GHK-Cu only 200 to 600 mcg per day, subcutaneous Best for systemic tissue support (skin, joints, hair, internal tissues) No fasting required Option B: Topical GHK-Cu only Applied to target areas once or twice daily Best for localized skin concerns (face, abdomen, specific areas of laxity) Lower cost, no injection required Option C: Injectable plus topical (recommended for maximum benefit) Injectable for systemic support plus topical for targeted skin areas Most thorough approach Addresses both internal tissue health and external skin quality Step 4: Improve and Maintain As semaglutide is titrated up over the following months, continue GHK-Cu consistently

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Some compounded formulations include B12 or other additives, but these don't typically affect constipation rates

The literature on combination pharmacology in these areas continues to grow

Patio-Cardona, S., Garrido-Miguel, M., Pascual-Morena, C., Berlanga-Macas, C., Lucern-Lucas-Torres, M., Alfaro-Gonzlez, S., & Martnez-Garca, I