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In the periphery, posttranslational processing of preproglucagon in the alpha-cells of the pancreas produces glucagon and a small amount of GLP-1 whereas the main source of peripheral GLP-1 production occurs through the posttranslational processing of preproglucagon in the L-cells of the gut (reviewed in Holst, 2007 and Campbell and Drucker, 2013)

J Lipid Res 37(12):25392549 Portincasa P, Venneman NG, Moschetta A, van den Berg A, Palasciano G, vanBerge-Henegouwen GP, van Erpecum KJ (2002) Quantitation of cholesterol crystallization from supersaturated model bile

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It makes insulin work better, reduces inflammation, and might protect the brain

Ozempic has data to support cardiovascular risk reduction, while Rybelsus does not, says Dr