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Serious Drug Allergies If you have ever had a severe allergic reaction to semaglutide (Ozempic/Wegovy), tirzepatide (Mounjaro/Zepbound), or any ingredient in these pens, you must avoid them

This is called biliary dyskinesia: the gallbladder isn't squeezing or emptying properly

That receptor count helps explain why these medicines are compared, but it should not be used alone to rank them

Can you switch from semaglutide GLP-1 to tirzepatide for weight loss

Important: If you experience severe, knifelike pain in the upper abdomen that spreads to your back, seek emergency care, as this may be a sign of acute pancreatitis