Neurochem Res 40:25272543 Higgins RD, Raju T, Edwards AD, Azzopardi DV, Bose CL, Clark RH, Ferriero DM, Guillet R, Gunn AJ, Hagberg H, Hirtz D, Inder TE, Jacobs SE, Jenkins D, Juul S, Laptook AR, Lucey JF, Maze M, Palmer C, Papile L, Pfister RH, Robertson NJ, Rutherford M, Shankaran S, Silverstein FS, Soll RF, Thoresen M, Walsh WF (2011) Hypothermia and other treatment options for neonatal encephalopathy: an executive summary of the Eunice Kennedy Shriver NICHD workshop
For diabetes management, reassessment is appropriate if A1c targets are not achieved after 36 months of therapy
The pricing starts from around 164/month making it one of the pricier options
NHS medicines: Topiramate
The biological mechanism (localized melanin accumulation) is identical, which is why the corrective approach is also the same