Speichinger explains
As mentioned earlier, the increased intake of proteins (processed, red meats), sugars, salt, saturated and trans fat, and refined carbohydrates, which are characteristic of the Western-style diet, leads to the development of many diseases, which have their basis in the occurrence of OxS (135)
Birsoy and colleagues also found that mitochondrial glutathione drives cancer spread: not by acting as an antioxidantan effect ruled out through multiple experimentsbut by signalling to activate ATF4, a transcription factor that helps cancer cells survive in low-oxygen conditions
i , Immunoblot analysis of SYVN1 from SLC33A1 -knockout HEK293T cells complemented with a vector control or SLC33A1 cDNA expressing sgRNA targeting intergenic region or two different sgRNAs targeting SYVN1
Cumming RC, Lightfoot J, Beard K, Youssoufian H, O'Brien PJ and Buchwald M