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The RCT by Kuzminski et al

Most copper peptide products are serums or creams and often have a faint blue tint, which comes from the copper itself

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(PubMed) Xiang G, Pu J, Yue L, Hou J, Sun H

Hence, a peptide was designed by substituting the negatively charged residues D42, D48, D49, E51, E56, and D57 within the p53 TAD PEP with alanine to increase its binding affinity to FOXO4 FHD and enhance membrane penetration