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When cytoplasmic concentrations of neurotransmitters rise dangerously high, TAAR1 activates G-protein-dependent signaling pathways that recruit intracellular kinases, including protein kinase C (PKC) and calcium/calmodulin-dependent protein kinase II (CaMKII) (Underhill et al., 2020)
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Executive Summary The GLP-1 receptor agonist (GLP-1 RA) drug class originally developed for type 2 diabetes but now a leading therapy for chronic weight management has experienced explosive demand growth that is straining global production capabilities
10.1002/mrd.21122 Mol
Marotta PJ, Graziadei IW, Ghent CN
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