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5-Methyl THF serves as a methyl donor in the vitamin B 12 -dependent reactions catalyzed by methionine synthase, which remethylates homocysteine to methionine, regenerating THF

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Parameters for the nonstandard residues -amino isobutyric acid (Aib) and dextroserine (dS) were obtained from CHARMM-GUI [64] and the SwissSidechain library [65], respectively, ensuring compatibility with the CHARMM36m force field parameters

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