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Dihydrotestosterone and estradiol deplete corticosensitive thymocytes lacking in receptors for these hormones
This dysbiotic state may compromise gut barrier integrity, creating a pro-inflammatory state
Thus, the inability to account for inhibition of IGF-2 binding to the IGF-1R is an important limitation in this study, which should be considered when assessing outcomes from human trials using IGF-1R mAbs
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No serious adverse events have been reported across extensive research use
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