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Mechanistic evaluation may include observation of compound interaction with signaling cascades involved in redox homeostasis, enzymatic activity, and molecular transport processes

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17 Importantly, paracetamol was not used for PDA closure in either group, and its use was limited to analgesic indications at standard neonatal dosing (24 mg/kg/day), which is substantially lower than the most common dosing regimen used for PDA management (60 mg/kg/day)