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The introduction of the SGLT2i and the GLP1RA both of which demonstrate excellent safety and potency - further development of GCGR agonists has stalled due to concerns of safety

3.6.3.3 Immune modulation Long-term use of proton pump inhibitors (PPI), while effective for acid-related disorders, has been shown to alter gut microbiota composition and increase the risk of infections such as SIBO and C