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On the other hand, TLR3 receptor activation in microglia leads to increased release of IL-1 and TNF-, which increases SERT expression in astrocytes and thus 5-HT reuptake and its degradation to the metabolite 5-HIAA, thereby reducing extracellular 5-HT levels (212216)
Incretin analogues that have been developed to treat type 2 diabetes hold promise as a novel treatment strategy for Alzheimers disease
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