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Influence of diverse chemical modifications on the ADME characteristics and toxicology of antisense oligonucleotides

Unlike many peptides that degrade quickly in the digestive system, BPC-157 demonstrates remarkable stability and bioavailability, making it effective through multiple administration routes including oral, subcutaneous, and intramuscular delivery

In this review, therapeutic strategies were divided into a therapeutic strategy focusing on the ferroptosis pathway and a therapeutic strategy focusing on metabolic vulnerability and nutrient addiction. However, mechanisms such as disulfide stress do not apply to either strategy