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Post-surgical patients
In the pituitary, CRH stimulates the secretion of adrenocorticotropic hormone (ACTH) (180, 213) and can induce the release of other pituitary hormones such as melanocytestimulating hormone (MSH) and endorphin (215)
Hydration helps flush out toxins and supports the detoxification process
Systemic inflammatory response syndrome (SIRS) following unregulated IV administration, presenting with fever above 41 degrees Celsius, acute liver injury, and clotting abnormalities, is also documented in a 2025 case report
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