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Benefits include weight loss, improved metabolic health, and reduced inflammation, all of which can contribute to fewer and less severe gout attacks

Furthermore, its significant anti-inflammatory properties have been demonstrated in epilepsy models, where it diminishes seizure severity by inhibiting the NLRP3 inflammasome (Wang et al., 2021), and in multiple sclerosis models, where it reduces demyelination and cognitive impairment (Sadek et al., 2023

Risk of bias was graded as unclear, high, or low

Whilst these medications slow gastric emptying, severe gastroparesis (stomach paralysis) is rare but has been reported and requires specialist assessment