Percent change in weight from baseline and proportion of patients achieving a weight loss of 5% were the co-primary endpoints
Ibrahim SS, Ibrahim RS, Arabi B, Brockmueller A, Shakibaei M, Busselberg D (2024) The effect of GLP-1R agonists on the medical triad of obesity, diabetes, and cancer
In the STEP 1 extension, people who stopped semaglutide regained 11.6 percentage points of body weight over 52 weeks, ending with an average net loss of 5.6% from baseline while lifestyle support continued (STEP 1 extension data)
[8] [10] The underlying pathophysiology involves changes in the hypothalamic thermoregulatory centre
Alcohol preference measurement To assess alcohol preference, the water and alcohol consumption was measured every 2 weeks for 12 h in the active period (18:006:00)