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The SURMOUNT-1 DXA substudy found that tirzepatide produced a 33.9% reduction in fat mass and a 10.9% reduction in lean mass over 72 weeks, with approximately 75% of total weight lost coming from fat and 25% from lean mass

If density declines significantly, interventions include calcium and vitamin D optimization, weight-bearing exercise, and sometimes pharmacologic therapy

Thus, the total carbon atoms at the beginning is 10 (5 + 5) and at the end is 10 (3 + 7)

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There are really fantastic research opportunities going forward to tease out these mechanisms, said Drucker, who began studying GLP-1 40 years ago