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Reassess before any escalation: A dose increase should follow a protocol need and a review of prior observations

Tirzepatide, used in medications like Mounjaro and Zepbound, showed even greater results, where participants in some trials lost up to 22.5% of their body weight

Establish the diagnosis by taking a careful history

The clinical outcomes data is robust and the benefit-risk profile, in appropriate patient populations, is well established

Testing may include SAM, SAH, methionine, homocysteine, whole-blood histamine, copper, zinc, ceruloplasmin, urinary pyrroles, organic acids, lactate, pyruvate, glutathione-related markers, 8-OHdG and lipid peroxides when clinically appropriate