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Stools that are hard, dry, or lumpy and difficult to pass
GLP-1 receptor is expressed in human stomach mucosa: analysis of its cellular association and distribution within gastric glands
Contraindications Retatrutide is not appropriate for people with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2), or those with a history of pancreatitis
Slower transit means food and waste spend more time in the colon, where water is progressively absorbed producing harder, drier stools
Because retatrutide also activates the GLP-1 receptor, the same preclinical concern applies [2]
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