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In TRIUMPH-4, 20.9% of participants on the 12mg dose reported dysesthesia , compared to just 0.7% on placebo
Common gastrointestinal side effects include nausea, vomiting, diarrhoea, constipation, and abdominal pain, which may overlap with Crohn's symptoms
The combination protocol increases the number of dose escalation events (since you are titrating two compounds), which may mean more frequent but generally mild headaches
It also lowered oxidative stress and damage in people with uncontrolled diabetes, despite high sugar levels
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