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The trial found no statistically significant difference between Sativex and placebo in subjective appetite ratings or in the appetite hormones GLP-1 and total ghrelin.What was Sativex compared with in this study?Sativex was compared with placebo in a double-blind, randomized, crossover design, so each participant received both a Sativex dose and a placebo dose on separate study days.How many people were in this trial?The analysis included 17 adults age 65 or older with poor appetite.What dose of Sativex was used?Participants received a single dose containing 8.1 mg THC and 7.5 mg CBD.What outcomes did the researchers measure?They measured postprandial GLP-1 and total ghrelin after one dose and a standardized breakfast, and tracked subjective appetite using visual analog scales across two doses, breakfast, and an ad libitum lunch.Did higher THC levels in the blood predict a bigger appetite effect?Higher plasma THC and metabolite concentrations trended toward lower GLP-1 and subjective appetite and higher ghrelin, but none of these associations reached statistical significance.Is this trial proof that cannabis-based medicines cannot help with appetite in older adults?No

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