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However, given that GLP-1R agonism in the VTA more robustly suppresses the intake of highly palatable foods compared to normal chow in drug-nave rodents 37,45,46 , it is likely that endogenous GLP-1 signaling in the VTA more selectively regulates hedonic rewards versus homeostatic signals 4

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These FDA-approved dosing schedules represent standard protocols, though individual patient circumstances may necessitate modifications under physician guidance

Understanding the established adverse effect profile of semaglutide provides essential context when evaluating new or unexpected symptoms during treatment, including musculoskeletal complaints such as lower back pain