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aureus aggravates AD skin lesions ( Reactive oxygen species are generated in response to different triggers such as allergens, cutaneous dysbiosis, exogenous irritants, pollutants and UV light ( 2 ), nitrate (NO 3 ), and biopyrrin, are significantly increased in AD patients ( To mitigate or avert oxidative damage induced by free radicals, the body has developed an intricate antioxidant defense mechanism

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Likewise, metformin reduces the development of oxidative stress and regulates autophagy in rats with high-fat diet through modulation of AMPK, SIRT1, and FOXO1 (Brakedal et al

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Others benefit from repeated cycles for chronic or complex issues