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(26-28) The duration of therapy and cumulative exposure to GLP-1 receptor agonists may also have played a role, as Werkman et al

Supraphysiological testosterone concentrations have been shown to reduce endothelial nitric oxide synthase expression and nitric oxide bioavailability, thereby favouring vasoconstriction and increased arterial stiffness (73)

Guanylate-binding protein 5 licenses caspase-11 for gasdermin-D mediated host resistance to Brucella abortus infection

Conversely, patients who respond well may continue treatment indefinitely as part of comprehensive weight management, similar to the approach used for other chronic conditions such as hypertension or diabetes