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When taken orally, semaglutide works by several complementary mechanisms: Enhances insulin release only when blood glucose is elevated Suppresses the release of glucagon, a hormone that raises blood sugar Slows stomach emptying, helping you feel fuller for longer May reduce appetite and caloric intake, underpinning its weight loss benefit This targeted approach helps reduce HbA1c and fasting plasma glucose, while also supporting significant, sustained weight loss in eligible patients

Addiction Medicine Program, Department of Psychiatry, UNC School of Medicine Lindsey Kennedy is a clinical psychiatric pharmacist at UNC Health and an Assistant Clinical Professor for the Department of Psychiatry at the University of North Carolina at Chapel Hill School of Medicine

Protein denitration/modification by glutathione-S-transferase and glutathione peroxidase

Eating antioxidant rich foods, maintaining good sleep habits, and reducing alcohol or pollution exposure can support better results from supplementation