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References References Selective and membranepermeable small molecule inhibitors of NNMT Roles of Nicotinamide NMethyltransferase in Obesity and Type 2 Diabetes Nicotinamide Nmethyltransferase inhibition mimics and boosts exercisemediated improvements in muscle function in aged mice Reduced calorie diet combined with NNMT inhibition establishes a healthier gut microbiome in obese mice Kraus et al

This is likely due to B12s role in metabolizing macronutrients like fats, carbohydrates, and proteins

bioRxiv , 2023.2010.2023.563621 (2023)

Inositol Inositol is a naturally occurring carbohydrate compound, historically grouped with the B-complex nutrients

Understanding why these symptoms occur and how to manage them helps ensure adequate B12 intake whilst minimising discomfort