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The SELECT cardiovascular outcomes trial published in 2023 added a cardiovascular benefit signal: semaglutide reduced major adverse cardiovascular events by 20% in overweight and obese patients with established cardiovascular disease, independent of diabetes status

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The consensus was to define resistance as lack of normalization of prolactin serum levels or lack of relevant mass shrinkage (30% reduction in maximum diameter) when treated with standard dopamine agonist doses (7.510 mg per day of bromocriptine or 2.0 mg per week of cabergoline) for at least 6 months

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So one of the things that BPC 157 does is help bring that ratio of glutamate and GABA more normal, it just in general