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20 December 2022

Mechanistically, PINK1-Parkin suppresses MDV dependent delivery of mitochondrial cargo into the endolysosomal system for antigen loading, thereby limiting mitochondrial antigen presentation (MitAP) under inflammatory stimuli, thereby coupling organelle surveillance decisions to adaptive immune monitoring (129)

Additionally, these medications have been shown to modestly reduce blood pressure and improve lipid profiles, further supporting cardiovascular health

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