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Importantly, this effect is immunomodulatory, not immunosuppressive , meaning it calms excessive inflammation without shutting down immune defense

Last reviewed: May 12, 2026 Last updated: May 12, 2026 Written by: Jay Hastings , CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations

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In a study in old mice, NNMT inhibition was shown to promote stem cell activation following injury

For men, testosterone's anabolic effects on skeletal muscle create an environment in which MOTS-c's enhancement of glucose uptake and mitochondrial biogenesis may be particularly well expressed, making MOTS-c a natural companion to testosterone optimization programs