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The follow-up pivotal trial (METAOD006 / OPTIONS) enrolled a larger cohort and failed to replicate statistically significant weight loss, which led Metabolic Pharmaceuticals to halt the formal drug development program in 2007

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Drugdrug and drugdisease interactions Steroids cause salt retention and antagonize thiazide action

O (Outcome): Primary outcome: changes in serum Vitamin B12 levels, clinical improvement of Vitamin B12 deficiency symptoms

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