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One of the mechanisms thought to be responsible for weight regain or plateau is a reduction in circulating levels of leptin after initial weight loss [11, 58]
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
For sublingual drops, an empty stomach is recommended but less critical since the medication absorbs through the mouth, not the stomach
Stronger satiety effects typically appear after stepping up to 0.5-1.0 mg/week
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