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Semaglutide produces more significant results and better maintains those results

Severe or persistent vomiting or diarrhea may lead to acute kidney injury in some cases

These comparative results align with the arm-level results for respective trials, with liraglutide having the smallest change from baseline (range 6.6% to 9.2%), followed by tirzepatide 5 mg ( 16.0%), semaglutide (range 16.6% to 17.1%), tirzepatide 10 mg ( 21.4%) and tirzepatide 15 mg ( 22.5%) (Supplementary Material Table S9)

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Approximately 80% of participants achieved clinically meaningful weight loss (5% of baseline weight)