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Additional References Nauck MA, DAlessio DA

doi: 10.1083/jcb.150.4.F107 51 RidleyA

The main reason is that the large amount of extracellular matrix deposition in the ovarian cancer microenvironment leads to tumor vascular collapse, reduced vascular perfusion, poor drug delivery and blocked migration of cytotoxic T cells to the tumor area (139)

However, the lack of extensive human clinical trials means long-term safety data in humans remains limited

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