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The result is greater weight loss than single-action GLP-1 drugs in clinical trials the SURMOUNT-1 trial reported average weight loss of 22.5% over 72 weeks at the 15 mg dose, compared to roughly 15% for semaglutides STEP-1 trial
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Serious concerns with unregulated/high-dose use: infections from non-sterile settings, kidney or liver stress at very high doses over time, and (rarely) thyroid disruption
In addition to diabetes and obesity, emerging data have demonstrated that GLP-1RAs reduce the rates of several other risk factors for PDAC (Fig
G., Mantovani, G
Many details remain under investigation
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