Comorbidities (hypertension, stroke, acute myocardial infarction, chronic kidney disease, dyslipidemia, and liver disease) were defined using ICD-10 codes, prescription data, and national health screening examination data
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Relapse was defined as an increase in the CGI-S score of 2 points compared with that obtained at week 12, as well as meeting the DSM-IV criteria for MDD at 2 consecutive visits at least 2 weeks apart, where the 2-week temporal criterion had to be satisfied at only the second visit