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2024 NEJM) is the cleanest evidence: 3,533 participants with type 2 diabetes and CKD, semaglutide cut the composite of kidney failure, cardiovascular death, and 50 percent eGFR decline by 24 percent over 3.4 years

Other rare adverse effects include pancreatitis and cholelithiasis

Current evidence quality : Most berberine studies are relatively small, short-term (typically 816 weeks), and conducted primarily in Asian populations, which may limit generalisability

Kanda N, Tamaki K

The present investigation evaluated the efficacy of Mesna with Celery seeds oil (MCSO) and Mesna plus Manuka Honey (MMH) in HC produced by CP in male adult rabbits