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The interaction of GLP-1 and GLP-1RAs with GLP-1Rs of the brain includes various molecular and cellular mechanisms that are the basis for translation into the clinic, since these mechanisms counteract many key links in the pathogenesis of brain diseases

IL-1 is a mediator of increases in slow-wave sleep induced by CRH receptor blockade

Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to the metabolic syndrome

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