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The main reason is that GSH-Au NCs@His does not have the capacity to form an Au-S bond, which greatly reduces the effectiveness of GSH-Au NCs@His to consume GSH, thus protecting tumor cells from ROS oxidative damage (Figure 7C)

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The Evolution From Diabetes Therapy to Weight Loss Treatment Semaglutide emerged as a once-weekly injectable GLP-1 agonist in 2017, initially approved by the FDA for type 2 diabetes management under the brand name Ozempic