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The affected enzymes, ERK1/2, along with their downstream targets, including c-Fos, c-Jun, and Egr-1, are believed to play significant roles in cell growth, migration, and angiogenesis, which is the development of new blood vessels

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Comparison with other studies Overall, events of suicidal ideation and self-harm have not been found to be imbalanced in clinical trials between randomised groups.67 However, these trials were limited by their sample sizes and thus could not detect these rare but potentially important adverse events

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