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These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility

The care is really supportive until the effects of the medication wear off. In some cases, it may be possible to manage symptoms at home after consulting with a health care professional, but other situations may require immediate medical attention, Billingsley noted