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Tirzepatide 10 and 15 mg also decreased large triglyceride-rich lipoprotein particles, small low-density lipoprotein particles, and lipoprotein insulin resistance score [60]

Postmortem analysis has revealed that insulin resistance (IR) also occur in AD patients brain with significantly decreased expression of the insulin receptor, concomitant with the disease progression (66, 67) and indicated that the defects in insulin signaling are associated with AD pathogenesis (68)

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The therapeutic hypothesis almost writes itself