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Common side effects include: Nausea Diarrhea Vomiting Constipation Abdominal pain These side effects are generally mild and tend to decrease over time as your body adjusts to the medication
Evaluate alternative absorption mechanisms
Furthermore, diuretics and other antihypertensives may potentiate dehydration secondary to GLP-1 RA-induced nausea and vomiting
Kong FJ, Wu JH, Sun SY, Ma LL, Zhou JQ
The researchers indicate that in mouse models of CKD or heart failure, the overactivation of the kidney-brain neural circuit leads to increased sympathetic nerve activity targeting both the kidneys and the heart (Cao et al., 2023)
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