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The treatment-regimen estimand represents the average treatment effect regardless of adherence to study intervention or initiation of prohibited weight management treatments

Although direct evidence for GLP-1RA use in PsA remains limited, the inclusion of PsA populations in these tirzepatide trials represents a conceptual shift toward testing immunometabolic interventions in inflammatory arthritis rather than restricting their evaluation to skin disease alone

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Because deep sleep is one of the most restorative phases of our sleep architecture, DSIP is of interest for those seeking to improve sleep quality, recovery, and even manage stress-induced interruptions in sleep patterns, promoting stress reduction