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Comparing Semaglutide to SGLT2 Inhibitors for Kidney Protection SGLT2 inhibitors (dapagliflozin, empagliflozin) remain the first-line add-on therapy for kidney protection in type 2 diabetes based on the DAPA-CKD (N=4,304) and EMPA-KIDNEY trials [8, 9]

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In primary care, faecal immunochemical testing (FIT) is now used to guide referral decisions

Four weeks of Pycnogenol intake led to a reduction of symptom severity by 20%, whereas it was reduced by 4.5% in placebo subjects

A post hoc analysis in Japan indicated that the combination of SGLT2i and GLP-1RA was superior to monotherapy in improving liver function parameters (ALT, AST), hepatic steatosis index (HSI), and fibrosis index (FIB-4), suggesting complementary mechanisms between the two