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These agents act through multiple mechanisms, including direct cardioprotection, vasodilation, natriuresis, weight reduction, lipid profile improvement, anti-inflammatory effects, renal protection, reduction in plaque formation, and neurohormonal regulation
While their metabolic benefits are established, concerns persist about a possible link with gastrointestinal (GI) cancers
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Theoretically the loss of lean mass could be prevented, but it is extremely difficult in practice, and therefore impossible (or highly unlikely) for most people
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