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Based on observational data, a 2011 report highlighted an increased risk of pancreatitis and pancreatic cancer in patients using incretin therapy (Elashoff et al., 2011), prompting a warning from the Food and Drug Administration (FDA) regarding the pancreatic safety of GLP-1 RAs (Franks et al., 2012) further heightened concerns about the potential adverse effects of GLP-1RAs on the pancreas, resulting in elevated pancreatic enzymes and AP