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Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles
Researchers looked at data from more than 430,000 patients aged 50 and older who took either a GLP-1, sodium-glucose cotransporter 2 inhibitors (SGLT2i), metformin or insulin to manage their diabetes for at least two years
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Clinical trials consistently show tirzepatide produces about 5% more body weight loss than semaglutide, likely due to this dual mechanism
The GLP-1 hormone was discovered in the 1980s
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![Structure of [ 3 H]liraglutide (top) and the GLP-1 receptor agonists](https://www.researchgate.net/profile/Inga-Bjornsdottir-2/publication/45650716/figure/fig2/AS:667822585806848@1536232720030/Structure-of-3-Hliraglutide-top-and-the-GLP-1-receptor-agonists-liraglutide-and.png)
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