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That increased pressure and prolonged acid exposure cause reflux in 1015% of patients, especially during dose increases

Its a big deal because the reductions observed were large, meaning that Canada is able to not only get drugs cheaper, but is able to buy just those drugs potentially associated with the best health outcomes and forgo the rest

5 , e583e583 (2015)

The secondary outcomes included the association with the individual components of major adverse cardiovascular events (myocardial infarction, ischaemic stroke, cardiovascular mortality), heart failure, and all cause mortality